何庆瑜

· 学院:生命科学技术学院

· 性别:

· 职称:教授博导

· 学院:生命科学技术学院

· 性别:

· 职称:教授博导

简介:

Qing-Yu He, PhD, FRSC

Professor and Director

Institute of Life and Health Engineering

College of Life Science and Technology

Jinan University

601 Huang-Pu Avenue West

Guangzhou 510632, China

Tel & Fax: 86-20-85227039

E-mail: tqyhe@jnu.edu.cn

Education:

         1995:        PhD, University of Sheffield, UK

         1988:        MSc, Jinan University / Sun Yat-Sen University, China

         1985:        BSc, Jinan University, China

Professional Experience:

         2005-Present: Professor, Jinan University, China

2002 – 2006:    Assistant Professor (Research), University of Hong Kong, Hong Kong

         1996 – 2002:    Postdoc - Research Assistant Professor, University of Vermont, USA

         1992 – 1992: Visiting Scholar, University of Oxford, UK

Associate Editor:   American Journal of Molecular and Cellular Biology

(http://uscip.org/JournalsDetail.aspx?journalID=14);

Associate Editor:   Journal of Integrated OMICS (http://www.jiomics.com);

Guest Editor:           Current Proteomics (www.bentham.org/cp)

Research Interests:

l  Cancer Proteomics: Biomarker, drug-target identification and validation.

l  Protein Biochemistry: Functional protein discovery and characterization.

Recent Publications:

1.         Gao, X., J. Feng, Y. He, F. Xu, X. Fan, W. Huang, H. Xiong, Q. Liu, W. Liu, X. Liu, X. Sun, Q. Y. He, Q. Zhang and L. Liu. "hnRNPK inhibits GSK3beta Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells." Sci Rep. 2016 Mar 14;6:22999.

2.         Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW, He QY, Cheung AL. "Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance. " Clin Cancer Res. 2016 Mar 1;22(5):1243-55.

3.          Lian, X., J. Guo, W. Gu, Y. Cui, J. Zhong, J. Jin, Q. Y. He@, T. Wang and G. Zhang. "Genome-Wide and Experimental Resolution of Relative Translation Elongation Speed at Individual Gene Level in Human Cells." PLoS Genet. 2016 Feb 29;12(2):e1005901.

4.         Yang, X. Y., K. He, G. Du, X. Wu, G. Yu, Y. Pan, G. Zhang, X. Sun and Q. Y. He@. "Integrated Translatomics with Proteomics to Identify Novel Iron-Transporting Proteins in Streptococcus pneumoniae." Front Microbiol. 2016 Feb 3;7:78.

5.         Yu, G. and Q. Y. He@. "ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization." Mol Biosyst. 2016 Jan 26; 12(2): 477-479.

6.         Zhang, H. T., L. F. Zeng, Q. Y. He, W. A. Tao, Z. G. Zha and C. D. Hu. "The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5." Biochim Biophys Acta. 2016 Feb; 1863(2): 335-346.

7.         Yang XY, Shi T, Du G, Liu W, Yin XF, Sun X, Pan Y, Q. Y. He,iTRAQ-Based Proteomics Revealed the Bactericidal Mechanism of Sodium New Houttuyfonate against Streptococcus pneumoniae. J Agric Food Chem2016 Aug 17;64(32):6375-82.

8.         Chen Z, Yang L, Cui Y, Zhou Y, Yin X, Guo J, Zhang G, Wang T, Q. Y. He, Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages. Oncotarget. 2016 Sep 1.

9.         Guo J, Cui Y, Yan Z, Luo Y, Zhang W, Deng S, Tang S, Zhang G, Q. Y. He, Wang “TPhosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP.” J Proteome Res. 2016 Nov 4;15(11):4060-4072.

10.     Wang Y, Huang ZH, Li YJ, He GW, Yu RY, Yang J, Liu WT, Li B, Q. Y. He, Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis. Apoptosis 2016 Dec;21(12):1438-1446.

11.     Fan X, Xiong H, Wei J, Gao X, Feng Y, Liu X, Zhang G, He QY@, Xu J@, Liu L@."Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation." Sci Rep. 2015 Dec 7;5:17732.

12.     Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F, He QY@, Zhang G@,  Wang T@. “Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.”, J Proteome Res. 2015 Sep 4;14(9):3645-57.

13.     Chen Y, Li Y, Zhong J, Zhang J, Chen Z, Yang L, Cao X, He QY@, Zhang G@, Wang T@. “Identification of Missing Proteins Defined by Chromosome-Centric Proteome Project in the Cytoplasmic Detergent-Insoluble Proteins.”, J Proteome Res. 2015 Sep 4;14(9):3693-709.

14.     Zhong J, Xiao C, Gu W, Du G, Sun X, He QY@, Zhang G@. “Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress.”, PLoS Genet. 2015 Jun 19;11(6):e1005302. doi: 10.1371/journal.pgen.1005302. eCollection 2015.

15.     Yu G@, Wang LG, He QY@. “ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization.”, Bioinformatics. 2015 Jul 15;31(14):2382-3.

16.     Yu G, Wang LG, Yan GR, He QY. “DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis.” Bioinformatics. 2015 Feb 15;31(4):608-9.

17.     Yang XY, Zhang L, Liu J, Li N, Yu G, Cao K, Han J, Zeng G, Pan Y, Sun X, He QY. “Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae.”,  J Proteomics. 2015 Feb 6;115:107-16.

18.     Zhong J. Y, Cui Y. Z, Guo J. H, Chen Z. P, Yang L. J, He QY, Zhang G, Wang T. “Resolving Chromosome-Centric Human Proteome with Translating mRNA Analysis: A Strategic Demonstration.”,  J Proteome Re.2014, 13(1): 50-9.

19.     Wang Q, Wen B, Wang T, Xu Z, Yin X, Xu S, Ren Z, Hou G, Zhou R, Zhao H, Zi J, Zhang S, Gao H, Lou X, Sun H, Feng Q, Chang C, Qin P, Zhang C, Li N, Zhu Y, Gu W, Zhong J, Zhang G, Yang P, Yan G, Shen H, Liu X, Lu H, Zhong F, He QY, Xu P, Lin L, Liu S. “Omics evidence: single nucleotide variants transmissions on chromosome 20 in liver cancer cell lines.”, J Proteome Res. 2014 Jan 3;13(1):200-11.

20.     Liu Y, Ying W, Ren Z, Gu W, Zhang Y, Yan G, Yang P, Liu Y, Yin X, Chang C, Jiang J, Fan F, Zhang C, Xu P, Wang Q, Wen B, Lin L, Wang T, Du C, Zhong J, Wang T, He QY, Qian X, Lou X, Zhang G, Zhong F. “Chromosome-8-coded proteome of Chinese Chromosome Proteome Data set (CCPD) 2.0 with partial immunohistochemical verifications.”, J Proteome Res. 2014 Jan 3;13(1):126-36.

21.     Li N, Yang XY, Guo Z, Zhang J, Cao K, Han J, Zhang G, Liu L, Sun X, He QY. “Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae.”, J Biol Inorg Chem. 2014 Aug;19(6):829-38.

22.     Li B, Tsao SW, Chan KW, Ludwig DL, Novosyadlyy R, Li YY, He QY, Cheung AL. “Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance-Implications for IGF-II and IGF-IR-Targeted Therapy.”, Clin Cancer Res. 2014 May 15;20(10):2651-62.

23.     Xiao CL, Mai ZB, Lian XL, Zhong JY, Jin JJ, He QY, Zhang G. “FANSe2: A Robust and Cost-Efficient Alignment Tool for Quantitative Next-Generation Sequencing Applications.”, PLoS One. 2014 Apr 17;9(4):e94250.

24.     Wang Y, He QY, Chiu JF. “Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.”, Eur J Pharmacol. 2014 Jul 15;735:52-8.

25.     Wang N, Zhang J, Zhang L, Yang XY, Li N, Yu G, Han J, Cao K, Guo Z, Sun X, He QY. “Proteomic analysis of putative heme-binding proteins in Streptococcus pyogenes.”, Metallomics. 2014 Aug;6(8):1451-9.

26.     Wu X, Xu L, Gu W, Xu Q, He QY, Sun X, Zhang G. “Iterative genome correction largely improves proteomic analysis of nonmodel organisms.” J Proteome Res. 2014 Jun 6;13(6):2724-34.

27.     Yang XY, Sun B, Zhang L, Li N, Han J, Zhang J, Sun X, He QY.  “Chemical Interference with Iron Transport Systems to Suppress Bacterial Growth of Streptococcus pneumoniae.” PLoS One. 2014 Aug 29;9(8):e105953.

28.     Yan GR, Tan Z, Wang Y, Xu ML, Yu G, Li Y, He QY, “Quantitative proteomics characterization on the antitumor effects of isodeoxyelephantopin against nasopharyngeal carcinoma.”, Proteomics. 2013 Nov;13(21):3222-32.

29.     Sun X, Yu G, Xu Q, Li N, Xiao C, Yin X, Cao K, Han J, He QY, “Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae.”, Metallomics. 2013 Jun 27;5(7):928-35.

30.     Xiao CL, Chen XZ, Du YL, Li ZF, Wei L, Zhang G, He QY, “Dispec: a novel peptide scoring algorithm based on peptide matching discriminability.”, PLoS One. 2013 May 13;8(5):e62724.

31.     Wang Q, Wen B, Yan G, Wei J, Xie L, Xu S, Jiang D, Wang T, Lin L, Zi J, Zhang J, Zhou R, Zhao H, Ren Z, Qu N, Lou X, Sun H, Du C, Chen C, Zhang S, Tan F, Xian Y, Gao Z, He M, Chen L, Zhao X, Xu P, Zhu Y, Yin X, Shen H, Zhang Y, Jiang J, Zhang C, Li L, Chang C, Ma J, Yan G, Yao J, Lu H, Ying W, Zhong F, He QY, Liu S. “Qualitative and quantitative expression status of the human chromosome 20 genes in cancer tissues and the representative cell lines.”, J Proteome Res. 2013 Jan 4;12(1):151-61.

32.     Wang T, Cui Y, Jin J, Guo J, Wang G, Yin X, He QY, Zhang G. “Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.”, Nucleic Acids Res. 2013 May;41(9):4743-54.

33.     Zhu YY, Yu G, Zhang Y, Xu Z, Wang YQ, Yan GR, He QY, “A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.”, Proteomics. 2013 Jan;13(1):169-78.

34.     Xiao CL, Chen XZ, Du YL, Sun X, Zhang G, He QY, "Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information.", J Proteome Res. 2013 Jan 4;12(1):328-35.

35.     Wang Q, Wen B, Yan G, Wei J, Xie L, Xu S, Jiang D, Wang T, Lin L, Zi J, Zhang J, Zhou R, Zhao H, Ren Z, Qu N, Lou X, Sun H, Du C, Chen C, Zhang S, Tan F, Xian Y, Gao Z, He M, Chen L, Zhao X, Xu P, Zhu Y, Yin X, Shen H, Zhang Y, Jiang J, Zhang C, Li L, Chang C, Ma J, Yan G, Yao J, Lu H, Ying W, Zhong F, He QY, Liu S, “Qualitative and Quantitative Expression Status of the Human Chromosome 20 Genes in Cancer Tissues and the Representative Cell Lines.”, J Proteome Res. 2013 Jan 4;12(1):151-61.

 

简介:
     何庆瑜博士,长江学者特聘教授。1995年获英国谢菲尔德大学(University of Sheffield)生物化学博士学位;曾任英国牛津大学(University of Oxford)访问学者,美国佛蒙特大学(University of Vermont)及香港大学助理教授(研究)2006年回国内后被国家人事部、科技部等七部委评为新世纪百千万人才工程国家级人选;2008年入选长江学者特聘教授;2010年获国务院政府特殊津贴;2011年获得广东省五一劳动奖章
     近年来一直致力于生物化学和功能蛋白质组学领域的研究工作,在感染和癌症相关蛋白质组学及抗肿瘤药物的作用机理等领域进行了系统的研究。在国际期刊上发表SCI论文170余篇,被引用4968次(截至201611月,Google: 6732),h-index: 33;相关科研成果获得美国国家癌症研究院(NCI)及美国NewsRX的专文评介。出版专著《功能蛋白质研究》及参编6部著作。近年来主持国家自然科学基金、国家重点基础研究发展计划“973”及香港政府RGC等项目和课题10项。是新加坡卫生部科研基金(NMRC)及南非国家医学研究基金(MRC)的评审专家;两种期刊《American Journal of Molecular and Cellular Biology》《Journal of Integrated OMICS》的副主编(Associate Editor)。
     现任暨南大学生命科学技术学院执行院长及暨南大学生命与健康工程研究院院长,教授,博士生导师;兼任基因药物国家工程研究中心副主任。是美国ASBMB会员,英国皇家化学会资深会员(Fellow, FRSC),中国蛋白质组学专业委员会副主任委员和蛋白质专业委员会委员。

 

 

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  • 更新日期:2017年3月28日